Protein Details: Aquaporin-1

Protein ID

ICDB_Pro_0541

Protein Name

Aquaporin-1

Gene Name

AQP1

Organism

Bos taurus (Bovine)

Length

271 amino acids

AlphaFoldDB

AF-P47865-F1-model_v4.pdb

Function

Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water; thereby permitting water to move in the direction of an osmotic gradient. Component of the ankyrin-1 complex; a multiprotein complex involved in the stability and shape of the erythrocyte membrane.

Sequence

MASEFKKKLFWRAVVAEFLAMILFIFISIGSALGFHYPIKSNQTTGAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISVLRAIMYIIAQCVGAIVATAILSGITSSLPDNSLGLNALAPGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSGPLAIGFSVALGHLLAIDYTGCGINPARSFGSSVITHNFQDHWIFWVGPFIGAALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK

PDB Structures

1J4N

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

SITE 58: "Substrate discrimination"; SITE 182: "Substrate discrimination"; SITE 191: "Hg(2+)-sensitive residue"; SITE 197: "Substrate discrimination"

Disease

Location

DOI ID

10.1006/bbrc.1994.2539; 10.1186/1471-2164-6-166; 10.1107/s0907444900008143; 10.1038/414872a

RefSeq

NP_777127.1